Public Lab regions are large areas that encompass multiple states or provinces, have their own umbrella mailing list, and may contain chapters with their own local mailing lists. Currently, regions are only laid out for the United States, but will expand.
- http://publiclab.org/wiki/northeast (contains five chapters)
- http://publiclab.org/wiki/southeast (contains one chapter)
- http://publiclab.org/wiki/midwest (contains one chapter)
- http://publiclab.org/wiki/gulf-coast (currently functioning as a single chapter)
- http://publiclab.org/wiki/norcal (currently functioning as a single chapter)