A Public Lab region is a large area that encompasses multiple states or provinces, has its own umbrella mailing list, and may contain chapters with their own local mailing lists. Currently, regions are only laid out for the United States, but will expand.
- http://publiclab.org/wiki/northeast (contains five chapters)
- http://publiclab.org/wiki/southeast (contains two chapters)
- http://publiclab.org/wiki/midwest (contains one chapter)
- http://publiclab.org/wiki/gulf-coast (currently functioning as a single chapter)
- http://publiclab.org/wiki/norcal (currently functioning as a single chapter)