A Public Lab region is a large area that encompasses multiple states or provinces, has its own umbrella mailing list, and may contain chapters with their own local mailing lists. To reinforce diversity, regions include both rural and urban areas, and tend to ignore political boundaries.
- http://publiclab.org/wiki/northeast (contains five chapters)
- http://publiclab.org/wiki/southeast (contains two chapters)
- http://publiclab.org/wiki/midwest (contains one chapter)
- http://publiclab.org/wiki/gulf-coast (currently functioning as a single chapter)
- http://publiclab.org/wiki/norcal (currently functioning as a single chapter)
- http://publiclab.org/wiki/northwest (contains two chapters)